Scientists have proposed a new concept for combating the aging of the body
The so-called zombie cells, which were previously considered exceptionally harmful factors of aging, can play a critical role in protecting and restoring the body. This was reported by Science Daily magazine on May 22.
A group of scientists from the Western Chinese Hospital of Sichuan University, led by Jian Deng and Dong Yang, found that senescent cells — those that have stopped dividing forever — have high heterogeneity. Traditionally, in medicine, it was believed that their accumulation in organs provokes chronic inflammation and age-related diseases. However, new data show that some types of such cells are necessary for wound healing, maintaining tissue balance, and embryo development.
Based on these data, this review summarizes the mechanisms of induction of cellular aging and the subsequent evolution of their functional phenotypes in various tissues.
The researchers emphasize that "zombie cells" are present in almost all systems: in the liver, lungs, heart, brain and skin. At the same time, some populations actually contribute to the development of cancer and tissue degeneration, while others limit fibrosis and help regeneration.
In this regard, scientists propose to switch to a strategy of "precision geroprotection": instead of completely destroying senescent cells, it is proposed to selectively affect only pathogenic groups. For this purpose, the use of CAR-T-cell therapy is being considered.
Experts warn that the widespread removal of senescent cells can disrupt immune surveillance and the stability of blood vessels in vital organs. The main obstacle to the introduction of the technology remains the lack of specific biomarkers that make it possible to accurately distinguish "useful" cells from "harmful" ones.
In the future, scientists plan to use spatial profiling and single-cell analysis technologies to create customized anti-aging therapy programs.
On May 21, nutritionist, PhD, doctor of preventive integrative medicine Rimma Moisenko spoke about methods of slowing down the aging process. First of all, she emphasized the importance of controlling total protein in the blood, and also recommended adding fats to breakfast — this will help maintain the functioning of the gallbladder and improve food absorption. In particular, the specialist advised soaking cereals to reduce the content of substances that interfere with the absorption of vitamins, and to use natural digestive stimulants.
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