Scientists have learned about the negative effects of caffeine on intestinal cells

Long-term exercise can cause acute damage to intestinal epithelial cells. A recent study showed that the addition of caffeine worsens these damages, and the effect on the intestine depends on the ADORA2A genotype. This is reported in an article published in the Wiley online library.

"Acute intestinal cell damage caused by endurance training may be exacerbated by caffeine, especially in sensitive people," the study says.

Scientists conducted an experiment with the participation of 18 volunteers. Male and female participants were given caffeine (3 mg/kg body weight) or a placebo before cycling. It is clarified that caffeine had an effect on increasing the level of molecules responsible for damage to intestinal cells after exercise. The result was especially noticeable in people with a certain ADORA2A genotype.

These results confirm the link between caffeine and intestinal disorders, which has previously been indicated in other studies. According to the publication, there are many mechanisms by which caffeine can affect the gastrointestinal tract. Allegedly, caffeine can affect the intestinal microflora and accelerate its disruption.

It is specified that during the experiment, two participants showed gastrointestinal symptoms in the form of nausea. The overall results of the study demonstrate that acute intestinal cell damage caused by exercise can be exacerbated by caffeine. Scientists believe that further research is needed on this issue.

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On November 28, Medical Xpress magazine reported a slowdown in the cellular aging process in people with severe mental disorders when drinking moderate amounts of coffee — no more than four cups a day. According to the publication, this amount of coffee is associated with longer markers of biological age — this corresponds to "minus five years" compared to people who do not drink this drink.

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