Perm scientists have created hybrid molecules that enhance the effectiveness of oncotherapy
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- Perm scientists have created hybrid molecules that enhance the effectiveness of oncotherapy
Scientists at Perm National Research Polytechnic University (PNRPU) have developed hybrid molecules that independently take on the necessary shape for targeted treatment in cancer therapy. This was announced on February 2 by the university's press service.
Molecular hybrids are single molecules that combine two or more therapeutic actions (for example, attacking a tumor and relieving inflammation). Modern technologies do not yet allow specialists to create a stable structure, without which a substance cannot reliably connect to a target in the body. This contributes to a loss of efficiency.
"To overcome this limitation, PNRPU scientists have developed a technique that forces a hybrid molecule to self—fold into a stable three-dimensional structure, and have successfully applied it, obtaining new compounds that may have anti-inflammatory and antitumor potential in their structure," the PNRPU press service quoted TASS as saying.
According to the press service, the analgesic substance antipyrine was used as a basis. Subsequently, scientists have created molecules that exhibit antitumor and anti-inflammatory activity. Such a solution, it is claimed, can help improve approaches to the treatment of both oncological diseases, as well as severe arthritis, joint psoriasis and Crohn's disease.
On January 11, Science Daily magazine reported on the ability of "dormant" immune cells inside a tumor to fight cancer. It was noted that the tumor environment suppresses the activity of macrophages, preventing them from performing a protective function. According to Professor Park Ji-ho, the study introduces a new concept of immunotherapy, in which anti-cancer immune cells are generated directly in the patient's body.
All important news is on the Izvestia channel in the MAX messenger.
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